Abstract: In 621 consecutive prostate cancer patients, the frequency of urinary tract infections (UTI) and marker loss was evaluated. They prophylactically received a single dose of non-broad-spectrum antibiotics and transrectal implantation of three thin needle fiducial markers, Gold Anchor ™ (GA). The occurrence of UTIs, sepsis, hospitalization due to infection, and marker loss after implantation […]
Category Archives: Clinical publications
Background and purpose: A GTV boost is suggested to result in higher complete response rates in rectal cancer patients, which is attractive for organ preservation. Fiducials may offer GTV position verification on (CB)CT, if the fiducial-GTV spatial relationship can be accurately defined on MRI. The study aim was to evaluate the MRI visibility of fiducials […]
Purpose: Triggered imaging is the use of kV image acquisition during treatment delivery to monitor intrafractional motion of implanted fiducials. An automatically identified fiducial point on the kV image is compared to its expected position predetermined from the treatment planning CT, and the treatment can be paused if the difference exceeds a user-definable tolerance. Conclusion: Triggered […]
Summary: Between 2015 and 2017, 96 patients had 3 Gold Anchor fiducial markers placed in conjunction with transperineal SpaceOar placement into the prostate at the University of Florida Health Proton Therapy Institute (UFPTI). None of these patients developed sepsis. The authors write in their discussion “Bacterial UTI following fiducial placement to facilitate treatment planning and […]
Background (extract): The aim of this video (Video 1, available online at www.VideoGIE.org) is to describe the technique for placement of EUS-guided fiducial markers in the treatment of locally advanced PC. Conclusion (extract): The application of SBRT to locally advanced or metastatic PC usually requires the use of fiducial markers to track the precise location […]
Summary: Gold Anchors were implanted percutaneously via the trans-thoracic route in lung in 80 patients for CyberKnife treatments at the Hartmann Radiotherapy Institute in France. This led to 9 cases (11%) of pneumothorax, out of which 2 cases (2.5%) required a drain. All implanted fiducials were effectively tracked by CyberKnife. Article in Radiation Oncology, 2019
Background: Fiducial markers are frequently used before treatment for imageguided patient setup in radiation therapy (RT), but can also be used during treatment for image‐guided intrafraction motion detection. This report describes our implementation of automatic marker detection with periodic kV imaging (TrueBeam v2.5) to monitor and correct intrafraction motion during prostate RT. Methods: We evaluated […]
Background: Preoperative neoadjuvant chemoradiation therapy (NACRT) is applied for resectable pancreatic cancer (RPC). To maximize the efficacy of NACRT, it is essential to ensure the accurate placement of fiducial markers for image-guided radiation. However, no standard method for delivering fiducial markers has been established to date, and the nature of RPC during NACRT remains unclear. […]
Objectives: To evaluate intrafractional fiducial marker position variations during stereotactic body radiotherapy (SBRT) in patients treated for liver metastases in visually guided, voluntary deep inspiration breath-hold (DIBH). Comment on methods: 10 patients with implanted fiducial markers were studied. Three DIBH CTs were acquired for treatment planning. Pre- and post-treatment CBCTs were acquired for each of […]
Summary: The effect on diffusion-weighted (DWI) MRI was evaluated of 0.28×10 mm Gold Anchor fiducial markers, implanted with a line shape. Conclusions: Gold fiducial markers demonstrated negligible effect on DWI quality. Therefore, it appears that the use of these markers does not preclude the optimal utilization of MRI, particularly DWI, during follow-up in prostate cancer […]